This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation.
The zeta chain-associated protein kinase of 70 kD, ZAP-70, is involved in T cell receptor signaling and is critical for T cell differentiation and function. Deficiency of ZAP-70 causes a combined immunodeficiency. Affected children present within the first two years of life with a history of ...
A common complication in allogenic bone marrow transplants and in some cases, it involves the oral mucosa. Therefore, the appropriate diagnosis and timely treatment is essential to prevent local complications which interfere with normal oral functions and facilitate infection spread.
A small organ in your upper chest, under your breastbone. Before birth and during childhood, the thymus helps the body make a type of white blood cell. These cells help protect you from infections.
A rare immunodeficiency disorder manifested by the partial or complete disappearance of major histocompatibility complex (MHC) proteins from the surface of the cells.
Autosomal recessive form of severe combined immunodeficiency (SCID) characterized by erythroderma, desquamation, alopecia, chronic diarrhea, failure to thrive, lymphadenopathy, and hepatosplenomegaly.
Reticular dysgenesis is the most severe form of inborn SCID. It is characterized by absence of granulocytes and almost complete deficiency of lymphocytes in peripheral blood, hypoplasia of the thymus and secondary lymphoid organs, and lack of innate and adaptive humoral and cellular immune ...
Hemoglobin-containing blood cell that transports oxygen from the lungs to tissues. In the tissues, the red blood cell exchanges its oxygen for carbon dioxide, which is brought back to the lungs to be exhaled.
