Lack of lymphocytes. When not more precisely defined, the term refers to pediatric patients. In MeSH, the term is assumed to refer to an infant or child. In children, it is usually defined in terms of weight, and can be evaluated either by a low weight for the child's age, or by a low rate of ...
One of the major virus families, to which the herpes simplex, varicella zoster, and Epstein-Barr viruses belong. Viruses in this family have a double-stranded linear molecular structure with icosahedral symmetry.
Autosomal recessive form of severe combined immunodeficiency (SCID) characterized by erythroderma, desquamation, alopecia, chronic diarrhea, failure to thrive, lymphadenopathy, and hepatosplenomegaly.
The CD3 complex is a group of cell surface molecules that associates with the T-cell antigen receptor (TCR) and functions in the cell surface expression of TCR and in the signaling transduction cascade that originates when a peptide:MHC ligand binds to the TCR. CD3 is composed of invariant ...
A rare immunodeficiency disorder manifested by the partial or complete disappearance of major histocompatibility complex (MHC) proteins from the surface of the cells.
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation.
Autosomal recessive disorder. Both parents need to pass the defective gene to their child in order for that child to inherit the deficiency.
